CDKN2C

Name

cyclin dependent kinase inhibitor 2C

Type

protein-coding

Position

50,960,745–50,974,634 (+)

Aliases

INK4C, p18, p18-INK4C

Ensembl

ENSG00000123080

RefSeq RNA

NM_001262.3, NM_001429675.1, NM_078626.3

RefSeq protein

NP_001253.1, NP_001416604.1, NP_523240.1

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cyclin dependent kinase inhibitor 2C

Symbol

CDKN2C

Biotype

Protein coding

Organism

Homo sapiens

Location

1:50,960,745-50,975,654

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein CDKN2C PDB 1bu9.png

via Wikidata · CC0