Structure via PubChem · Public domain (PubChem)
dimethindene
Sign in to saveAlso known as Dimetindene
Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation selective H1 antagonist. Dimetindene is an atypical first generation H1 antagonist as it only minimally passes across the blood–brain barrier.
Chemical data
- Formula
- C20H24N2
- Molecular weight
- 292.4 g/mol
- IUPAC name
- N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
- SMILES
- CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
- InChIKey
- MVMQESMQSYOVGV-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 16.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
242 papers- Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.Cell · 2017
- Transdermal absorption of dimethindene in man.Archiv der Pharmazie · 1995
- Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach.Molecules (Basel, Switzerland) · 2022
- Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.Journal of medicinal chemistry · 2003
- Effect-kinetic characterization of dimethindene maleate following oral administration (Fenistil, Tropfen).Fundamental & clinical pharmacology · 1990
via PubMed
Wikidata facts
- Mass
- 292.194
Show 4 more facts
- chemical formula
- C₂₀H₂₄N₂
- Commons category
- Dimetindene
- canonical SMILES
- CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
- defined daily dose
- 4
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Medical use
- Names
- References
Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation selective H1 antagonist. Dimetindene is an atypical first generation H1 antagonist as it only minimally passes across the blood–brain barrier.
Dimetindene is also an M2 receptor antagonist.
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via Wikidata sitelinks · CC0
Connections
atropine
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histamine antagonist
Entity
muscarinic acetylcholine receptor family
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(RS)-meclizine
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dibucaine
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H1 antagonist
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International Standard Book Number
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Mentha
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salt
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digital object identifier
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chemical formula
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camphor
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molar mass
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Q180686
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histamine
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acetylcholine
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L-histidine
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antidepressant
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CAS Registry Number
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Mamba
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