Structure via PubChem · Public domain (PubChem)
dimethindene
Sign in to saveAlso known as Dimetindene
Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation selective H1 antagonist. Dimetindene is an atypical first generation H1 antagonist as it only minimally passes across the blood–brain barrier.
In the Vinony graph
Vinony's link graph records 600 inbound references to dimethindene, and connects out to atropine, histamine antagonist and muscarinic acetylcholine receptor family.
Vinony files it under 2-Pyridyl compounds, Dimethylamino compounds and ECHA InfoCard ID from Wikidata.
Vinony links it to 19 Wikipedia language editions.
Chemical data
- Formula
- C20H24N2
- Molecular weight
- 292.4 g/mol
- IUPAC name
- N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
- SMILES
- CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
- InChIKey
- MVMQESMQSYOVGV-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 16.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Pruritus, allergic disease
via ChEMBL · EBI
Research
242 papers- Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.Cell · 2017
- Transdermal absorption of dimethindene in man.Archiv der Pharmazie · 1995
- Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach.Molecules (Basel, Switzerland) · 2022
- Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.Journal of medicinal chemistry · 2003
- Effect-kinetic characterization of dimethindene maleate following oral administration (Fenistil, Tropfen).Fundamental & clinical pharmacology · 1990
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 292.194
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₀H₂₄N₂
- subject has role
- antipruritic
- Commons category
- Dimetindene
- canonical SMILES
- CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
- defined daily dose
- 4
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Medical use
- Names
- References
Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation selective H1 antagonist. Dimetindene is an atypical first generation H1 antagonist as it only minimally passes across the blood–brain barrier.
Dimetindene is also an M2 receptor antagonist.
Excerpted from Wikipedia’s “dimethindene” article, available under the CC BY-SA 4.0 licence.
Available in 19 languages
- Deutsch
- 中文
- Português
- Italiano
- العربية
- Bahasa Indonesia
- Greek
- Hebrew
- Hungarian
- Nederlands
- Polski
- Romanian
- Serbian
- Serbian (Latin)
- Tiếng Việt
- Ukrainian
- فارسی
- ไทย
via Wikidata sitelinks · CC0