GPBAR1

Name

G protein-coupled bile acid receptor 1

Type

protein-coding

Position

218,259,496–218,263,861 (+)

Aliases

BG37, GPCR19, GPR131, M-BAR, TGR5

Ensembl

ENSG00000179921

RefSeq RNA

NM_001077191.2, NM_001077194.2, NM_001321950.2, NM_170699.3, XM_011510743.1

RefSeq protein

NP_001070659.1, NP_001070662.1, NP_001308879.1, NP_733800.1, XP_011509045.1

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

G protein-coupled bile acid receptor 1

Symbol

GPBAR1

Biotype

Protein coding

Organism

Homo sapiens

Location

2:218,259,496-218,263,861

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0