IGLL1

Name

immunoglobulin lambda like polypeptide 1

Type

protein-coding

Position

23,573,125–23,580,302 (−)

Aliases

14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2

Ensembl

ENSG00000128322

RefSeq RNA

NM_001369906.1, NM_020070.4, NM_152855.3

RefSeq protein

NP_001356835.1, NP_064455.1, NP_690594.1

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

immunoglobulin lambda like polypeptide 1

Symbol

IGLL1

Biotype

Protein coding

Organism

Homo sapiens

Location

22:23,573,125-23,580,302

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein IGLL1 PDB 2h32.png

via Wikidata · CC0