KLF14
Sign in to saveAlso known as BTEB5, Kruppel-like factor 14, Kruppel like factor 14
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.
In the Vinony graph
Within Vinony's link graph, KLF14 is referenced by 814 other articles, and connects out to PubMed, Online Mendelian Inheritance in Man and human chromosome 7.
It sits within the topics Genes on human chromosome 7 and Transcription factors.
Its subject is documented across 6 Wikipedia language editions.
Gene data
KLF14- Name
- KLF transcription factor 14
- Type
- protein-coding
- Position
- 130,730,697–130,734,207 (−)
- Aliases
- BTEB5
- Ensembl
- ENSG00000266265
- RefSeq RNA
- NM_138693.4
- RefSeq protein
- NP_619638.2
This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
KLF transcription factor 14
- Symbol
- KLF14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:130,730,697-130,734,207
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 76469
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/136259
- chromosome
- human chromosome 7
- genomic start
- 130730697
- genomic end
- 130734207
- cytogenetic location
- 7q32.2
- expressed in
- smooth muscle tissue
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Protein structure
- Clinical significance
- References
- External links
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.
== Function == KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression.
Excerpted from Wikipedia’s “KLF14” article, available under the CC BY-SA 4.0 licence.