KLF14

Also known as BTEB5, Kruppel-like factor 14, Kruppel like factor 14

Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.

Gene data

KLF14

Name: KLF transcription factor 14
Type: protein-coding
Position: 130,730,697–130,734,207 (−)
Aliases: BTEB5
Ensembl: ENSG00000266265
RefSeq RNA: NM_138693.4
RefSeq protein: NP_619638.2

This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

~1 min read

Article

5 sections

Contents

Function
Protein structure
Clinical significance
References
External links

== Function == KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression.