KLF8

Also known as BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

Gene data

KLF8

Name: KLF transcription factor 8
Type: protein-coding
Chromosome: X
Position: 56,232,356–56,291,531 (+)
Aliases: BKLF3, ZNF741
Ensembl: ENSG00000102349
RefSeq RNA: NM_001159296.2, NM_001324099.1, NM_001324100.1, NM_001324102.1, NM_001324104.1
RefSeq protein: NP_001152768.1, NP_001311028.1, NP_001311029.1, NP_001311031.1, NP_001311033.1

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

Gene Ontology

Biological process

~1 min read

Article

4 sections

Contents

Interactions
References
Further reading
External links

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

== Interactions ==