KMT2C

Also known as HALR, MLL3, lysine methyltransferase 2C, KLEFS2

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.

In the Vinony graph

Vinony's link graph records 821 inbound references to KMT2C, and connects out to PubMed, homeobox and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 7 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

KMT2C

Name: lysine methyltransferase 2C
Type: protein-coding
Position: 152,134,922–152,436,656 (−)
Aliases: HALR, KLEFS2, MLL3
Ensembl: ENSG00000055609
RefSeq RNA: NM_001446885.1, NM_001446993.1, NM_021230.2, NM_170606.3
RefSeq protein: NP_001433814.1, NP_001433922.1, NP_733751.2

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

chromatin remodeling regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II

Molecular function

transcription coactivator activity RNA binding protein binding histone methyltransferase activity histone H3K4 methyltransferase activity histone H3K4 methyltransferase activity histone H3K4 monomethyltransferase activity histone H3K4 monomethyltransferase activity

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm cytosol histone methyltransferase complex MLL3/4 complex

Pathways

Lysine degradation - Homo sapiens (human)Developmental Biology Adaptive Immune System Adaptive Immune System Immune System Immune System Epigenetic regulation of gene expression Epigenetic regulation of gene expression Generic Transcription Pathway PKMTs methylate histone lysines

via MyGene.info

Gene · Ensembl

lysine methyltransferase 2C

Symbol: KMT2C
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:152,134,922-152,436,656
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MLL3 PDB 2YSM.png

Show 8 more facts

HomoloGene ID: 46480
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/58508
genomic end: 152436644
genomic start: 151832010
chromosome: human chromosome 7
cytogenetic location: 7q36.1
expressed in: seminal vesicula

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

6 sections

Contents

Function
Interactions
Clinical significance
References
Further reading
External links

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.

== Function ==

Excerpted from Wikipedia’s “KMT2C” article, available under the CC BY-SA 4.0 licence.