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GeneQ4042415· pop 6· linked from 367 articles

LAMP3

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Also known as CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403, lysosomal-associated membrane protein 3

Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. It is one of the lysosome-associated membrane glycoproteins.

Gene data

LAMP3
Name
lysosome associated membrane protein 3
Type
protein-coding
Position
183,122,013–183,163,839 (−)
Aliases
CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403
Ensembl
ENSG00000078081
RefSeq RNA
NM_014398.4, XM_005247360.6, XM_011512688.3, XM_047447967.1, XM_054346166.1
RefSeq protein
NP_055213.2, XP_005247417.1, XP_011510990.1, XP_047303923.1, XP_054202141.1

This gene encodes lysosome-associated membrane glycoprotein 3, a type 1 integral membrane protein that belongs to a family of lysosome associated membrane proteins which form part of the glycoconjugate coat present on the inside of the lysosomal membrane. It is predominantly expressed in mature dendritic cells and serves as a marker of dendritic cell maturation. The encoded protein localizes primarily to late endosomes/lysosomes and the MHC class II compartment, where it contributes to antigen processing and presentation during adaptive immune responses. The expression of this gene is inducible under hypoxic conditions via hypoxia-inducible factor 1-alpha signaling. In cancer, this gene is frequently overexpressed and is associated with tumor progression, metastasis, therapy resistance, and poor clinical prognosis in multiple malignancies including breast, cervical, and ovarian cancers. [provided by RefSeq, Feb 2026].

Gene Ontology

Pathways

Lysosome - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

lysosomal associated membrane protein 3

Symbol
LAMP3
Biotype
Protein coding
Organism
Homo sapiens
Location
3:183,122,013-183,163,839
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
8670
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/27074
chromosome
human chromosome 3
genomic start
183122215
genomic end
182881627
cytogenetic location
3q27.1
Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

4 sections
Contents
  • Structure and Tissue Distribution
  • References
  • Further reading
  • External links

Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. It is one of the lysosome-associated membrane glycoproteins.

LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. In humans, this protein is almost exclusively found in mature Dendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in the MHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response. LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar cells.

Excerpted from Wikipedia’s “LAMP3” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0