LAMP3

Also known as CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403, lysosomal-associated membrane protein 3

Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. It is one of the lysosome-associated membrane glycoproteins.

Gene data

LAMP3

Name: lysosome associated membrane protein 3
Type: protein-coding
Aliases: CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403

This gene encodes lysosome-associated membrane glycoprotein 3, a type 1 integral membrane protein that belongs to a family of lysosome associated membrane proteins which form part of the glycoconjugate coat present on the inside of the lysosomal membrane. It is predominantly expressed in mature dendritic cells and serves as a marker of dendritic cell maturation. The encoded protein localizes primarily to late endosomes/lysosomes and the MHC class II compartment, where it contributes to antigen processing and presentation during adaptive immune responses. The expression of this gene is inducible under hypoxic conditions via hypoxia-inducible factor 1-alpha signaling. In cancer, this gene is frequently overexpressed and is associated with tumor progression, metastasis, therapy resistance, and poor clinical prognosis in multiple malignancies including breast, cervical, and ovarian cancers. [provided by RefSeq, Feb 2026].

via MyGene.info

Gene · Ensembl

lysosomal associated membrane protein 3

Symbol: LAMP3
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:183,122,013-183,163,839
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8670
exact match: identifiers.org/ncbigene/27074
genomic start: 183122215
genomic end: 182881627
cytogenetic location: 3q27.1

Sources (3)

via Wikidata · CC0

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Article

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Contents

Structure and Tissue Distribution
References
Further reading
External links

Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. It is one of the lysosome-associated membrane glycoproteins.

LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. In humans, this protein is almost exclusively found in mature Dendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in the MHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response. LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar cells.