MAP3K20
Sign in to saveAlso known as AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.
In the Vinony graph
Vinony's link graph records 306 inbound references to MAP3K20, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It sits within the topics EC 2.7.11 and Genes on human chromosome 2.
Vinony links it to 6 Wikipedia language editions.
Gene data
MAP3K20- Name
- mitogen-activated protein kinase kinase kinase 20
- Type
- protein-coding
- Position
- 173,057,181–173,268,909 (+)
- Aliases
- AZK, CNM6, MLK7, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, SFMMP, ZAK
- Ensembl
- ENSG00000091436
- RefSeq RNA
- NM_016653.3, NM_133646.3, XM_005246640.3, XM_017004323.2, XM_017004324.2
- RefSeq protein
- NP_057737.2, NP_598407.1, XP_005246697.1, XP_016859812.1, XP_016859813.1
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase 20
- Symbol
- MAP3K20
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:173,057,181-173,268,909
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 32331
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51776
- genomic end
- 173268015
- genomic start
- 173940163
- chromosome
- human chromosome 2
- cytogenetic location
- 2q31.1
- expressed in
- seminal vesicula
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Excerpted from Wikipedia’s “MAP3K20” article, available under the CC BY-SA 4.0 licence.