Structure via PubChem · Public domain (PubChem)
mequitazine
Sign in to saveAlso known as Kitazemin, Mequitazina, Mequitazinum
Mequitazine (trade name Primalan) is an H1 antagonist and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.
In the Vinony graph
Vinony's link graph records 652 inbound references to mequitazine, and connects out to atropine, histamine antagonist and muscarinic acetylcholine receptor family.
Vinony files it under Cleanup tagged articles with a reason field from March 2021, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Vinony links it to 10 Wikipedia language editions.
Chemical data
- Formula
- C20H22N2S
- Molecular weight
- 322.5 g/mol
- IUPAC name
- 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine
- SMILES
- C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
- InChIKey
- HOKDBMAJZXIPGC-UHFFFAOYSA-N
- XLogP
- 4.6
- Polar surface area
- 31.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- allergic disease
via ChEMBL · EBI
Research
153 papers- Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity.Frontiers in pharmacology · 2024
- [Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review].Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) · 2008
- Second-Generation H(1)-Receptor Antagonists, Mequitazine, Azelastine and Desloratadine Activate Caspase-8, Caspase-3, and Gasdermin E and Induce Cell Death Showing Pyroptotic-Like Features in Macrophages at Excessively High Concentrations.Biological & pharmaceutical bulletin · 2025
- Photodegradation and photostability-indication of mequitazine.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2009
- Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.The Journal of pharmacology and experimental therapeutics · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 322.15037
- Has use
- medication
Show 5 more facts
- canonical SMILES
- C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
- chemical formula
- C₂₀H₂₂N₂S
- defined daily dose
- 10
- subject has role
- H1 antagonist
- Commons category
- Mequitazine
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
8 sectionsContents
- Contraindications
- Special precautions
- Adverse reactions
- Drug interactions
- Synthesis
- References
- Further reading
- External links
Mequitazine (trade name Primalan) is an H1 antagonist and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.
It was patented in 1969 and came into medical use in 1976.
Excerpted from Wikipedia’s “mequitazine” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 10 languages
via Wikidata sitelinks · CC0