RBL2
Sign in to saveAlso known as P130, Rb2, retinoblastoma-like 2, RB transcriptional corepressor like 2, BRUWAG
protein-coding gene in the species Homo sapiens
Gene data
RBL2- Name
- RB transcriptional corepressor like 2
- Type
- protein-coding
- Position
- 53,433,977–53,491,649 (+)
- Aliases
- BRUWAG, P130, Rb2
- Ensembl
- ENSG00000103479
- RefSeq RNA
- NM_001323608.2, NM_001323609.2, NM_001323610.2, NM_001323611.1, NM_005611.4
- RefSeq protein
- NP_001310537.1, NP_001310538.1, NP_001310539.1, NP_001310540.1, NP_005602.3
Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
regulation of DNA-templated transcriptionregulation of transcription by RNA polymerase IInegative regulation of gene expressioncell differentiationregulation of lipid kinase activitynegative regulation of DNA-templated transcriptionregulation of cell cyclenegative regulation of G1/S transition of mitotic cell cycle
Molecular function
Pathways
FoxO signaling pathway - Homo sapiens (human)Cell cycle - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Transcription of E2F targets under negative control by DREAM complexTranscription of E2F targets under negative control by DREAM complexTranscription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1G0 and Early G1
via MyGene.info
Gene · Ensembl
RB transcriptional corepressor like 2
- Symbol
- RBL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:53,433,977-53,491,668
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Research
565 papers- The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms.Nature communications · 2024
- RBL2 Regulates Cardiac Sensitivity to Anthracycline Chemotherapy.JACC. CardioOncology · 2023
- Loss of Rbl2 (Retinoblastoma-Like 2) Exacerbates Myocardial Ischemia/Reperfusion Injury.Journal of the American Heart Association · 2022
- RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis.Cell death & disease · 2024
- RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling.Cell reports · 2023
via PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4098
- exact match
- identifiers.org/ncbigene/5934
- genomic end
- 53491648
- genomic start
- 53467889
- cytogenetic location
- 16q12.2
Sources (4)
via Wikidata · CC0
Connections
Q180686
Entity
homeobox
Entity
Ensembl genome database project
Entity
PDX1
Gene
protein
Entity
Wikidata
Entity
gene
Entity
chromosome
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public domain
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digital object identifier
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bibcode
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human genome
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Q229883
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base pair
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locus
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Medical Subject Headings
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gene expression
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Online Mendelian Inheritance in Man
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United States National Library of Medicine
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transcription factor
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