ADGRE3

Also known as EMR3, adhesion G protein-coupled receptor E3

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

In the Vinony graph

Vinony's link graph records 484 inbound references to ADGRE3, and connects out to PubMed, Ensembl genome database project and protein.

It sits within the topics Genes on human chromosome 19 and G protein-coupled receptors.

Vinony links it to 5 Wikipedia language editions.

Gene data

ADGRE3

Name: adhesion G protein-coupled receptor E3
Type: protein-coding
Position: 14,599,080–14,690,027 (−)
Aliases: EMR3
Ensembl: ENSG00000131355
RefSeq RNA: NM_001289158.2, NM_001289159.2, NM_032571.5, NM_152939.1, XM_011528374.3
RefSeq protein: NP_001276087.1, NP_001276088.1, NP_115960.2, XP_011526676.1, XP_047295502.1

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014].

Gene Ontology

Biological process

cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway

Molecular function

transmembrane signaling receptor activity G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity calcium ion binding

Cellular component

extracellular region plasma membrane plasma membrane plasma membrane membrane membrane secretory granule membrane ficolin-1-rich granule membrane

Pathways

Signal Transduction Innate Immune System Immune System Signaling by GPCR Class B/2 (Secretin family receptors)GPCR ligand binding Neutrophil degranulation GPCRs, Other

via MyGene.info

Gene · Ensembl

adhesion G protein-coupled receptor E3

Symbol: ADGRE3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:14,599,080-14,690,027
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 50009
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84658
genomic end: 14800839
genomic start: 14729929
chromosome: human chromosome 19
cytogenetic location: 19p13.12
expressed in: gallbladder

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Ligands
References
External links

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.

Excerpted from Wikipedia’s “ADGRE3” article, available under the CC BY-SA 4.0 licence.