ADGRE2

Also known as CD312, VBU, EMR2, adhesion G protein-coupled receptor E2, CD97

EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Gene data

ADGRE2

Name: adhesion G protein-coupled receptor E2
Type: protein-coding
Position: 14,732,392–14,778,560 (−)
Aliases: CD312, CD97, EMR2, VBU
Ensembl: ENSG00000127507
RefSeq RNA: NM_001271052.1, NM_013447.4, NM_152916.2, NM_152917.2, NM_152918.1
RefSeq protein: NP_001257981.1, NP_038475.2, NP_690880.1, NP_690881.1, XP_011526250.1

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].

Gene Ontology

Biological process

Article

7 sections

Contents

Ligand
Signaling
Function
Clinical significance
See also
References
External links

EMR2 is expressed by monocytes/macrophages, dendritic cells and all types of granulocytes. In the case of EMR2 the N-terminal domains consist of alternatively spliced epidermal growth factor-like (EGF-like) domains. EMR2 is closely related to CD97 with 97% amino-acid identity in the EGF-like domains. The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human. Mice lack the Emr2 gene. This gene is closely linked to the gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19.