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GeneQ17836876· pop 6· linked from 815 articles

BACH1

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Also known as BACH-1, BTBD24, BTB domain and CNC homolog 1

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

In the Vinony graph

Vinony's link graph records 815 inbound references to BACH1, and connects out to PubMed, human chromosome 21 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 21 and Transcription factors.

Vinony links it to 6 Wikipedia language editions.

Gene data

BACH1

Name: BTB domain and CNC homolog 1
Type: protein-coding
Position: 29,194,071–29,630,751 (+)
Aliases: BACH-1, BTBD24
Ensembl: ENSG00000156273
RefSeq RNA: NM_001011545.1, NM_001186.4, NM_206866.3, NR_027655.3
RefSeq protein: NP_001177.1, NP_996749.1

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II DNA repair regulation of DNA-templated transcription regulation of DNA-templated transcription regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleus nucleus nucleoplasm

Pathways

Cellular responses to stress Cellular responses to stimuli Cytoprotection by HMOX1 Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulating anti-oxidant/detoxification enzymes

via MyGene.info

Gene · Ensembl

BACH transcriptional regulator 1

Symbol: BACH1
Biotype: Protein coding
Organism: Homo sapiens
Location: 21:29,194,071-29,630,751
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein BACH1 PDB 2ihc.png

Show 9 more facts

HomoloGene ID: 916
genetic association: pancreatic cancer
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/571
chromosome: human chromosome 21
genomic start: 30566392
genomic end: 31003071
cytogenetic location: 21q21.3
expressed in: amniotic fluid

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
See also
References
Further reading
External links

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

== Function ==

Excerpted from Wikipedia’s “BACH1” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 21 Transcription factors