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GeneQ18045327· pop 6· linked from 812 articles

BACH2

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Also known as BTBD25, BTB domain and CNC homolog 2, IMD60

Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus.

In the Vinony graph

Within Vinony's link graph, BACH2 is referenced by 812 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 6 and Transcription factors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

BACH2

Name: BACH transcriptional regulator 2
Type: protein-coding
Position: 89,926,528–90,296,982 (−)
Aliases: BTBD25, IMD60
Ensembl: ENSG00000112182
RefSeq RNA: NM_001170794.2, NM_021813.4
RefSeq protein: NP_001164265.1, NP_068585.1

Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Implicated in immunodeficiency 60. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II primary adaptive immune response involving T cells and B cells

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm

Pathways

Adaptive Immune System Immune System Somatic hypermutation of immunoglobulin genes Immunoglobulin maturation Affinity selection of immunoglobulins

via MyGene.info

Gene · Ensembl

BACH transcriptional regulator 2

Symbol: BACH2
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:89,926,528-90,296,982
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: 3ohu.png

Show 8 more facts

HomoloGene ID: 7240
genetic association: celiac disease
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/60468
genomic end: 90296843
genomic start: 90636248
chromosome: human chromosome 6
cytogenetic location: 6q15

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus.

== References ==

Excerpted from Wikipedia’s “BACH2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 6 Transcription factors