Also known as MODY11, BLK proto-oncogene, Src family tyrosine kinase
protein-coding gene in the species Homo sapiens
Gene data
BLK- Name
- BLK proto-oncogene, Src family tyrosine kinase
- Type
- protein-coding
- Position
- 11,486,894–11,564,599 (+)
- Aliases
- MODY11
- Ensembl
- ENSG00000136573
- RefSeq RNA
- NM_001330465.2, NM_001715.3, XM_011543824.2, XM_011543825.4, XM_011543827.2
- RefSeq protein
- NP_001317394.1, NP_001706.2, XP_011542126.1, XP_011542127.1, XP_011542129.1
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010].
Gene Ontology
Biological process
immune response-activating cell surface receptor signaling pathwaycell surface receptor protein tyrosine kinase signaling pathwaypeptidyl-tyrosine phosphorylationcell differentiationpositive regulation of insulin secretionintracellular signal transductionintracellular signal transductionB cell receptor signaling pathway
Molecular function
protein kinase activityprotein tyrosine kinase activityprotein tyrosine kinase activityprotein tyrosine kinase activitynon-membrane spanning protein tyrosine kinase activitynon-membrane spanning protein tyrosine kinase activitynon-membrane spanning protein tyrosine kinase activitynon-membrane spanning protein tyrosine kinase activity
Cellular component
Pathways
Adaptive Immune SystemImmune SystemGeneric Transcription PathwayRNA Polymerase II TranscriptionGene expression (Transcription)Transcriptional regulation by RUNX1RUNX1 regulates transcription of genes involved in BCR signalingAntigen activates B Cell Receptor (BCR) leading to generation of second messengersSignaling by the B Cell Receptor (BCR)Apoptosis Modulation and Signaling
via MyGene.info
Gene · Ensembl
BLK proto-oncogene, Src family tyrosine kinase
- Symbol
- BLK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:11,486,894-11,564,599
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1297
- genomic end
- 11564599
- exact match
- identifiers.org/ncbigene/640
- genomic start
- 11486894
- cytogenetic location
- 8p23.1
Sources (4)
via Wikidata · CC0
Connections
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Ensembl genome database project
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