CD163
Sign in to saveAlso known as M130, MM130, SCARI1, CD163 molecule
CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. It also is a marker of cells from the monocyte/macrophage lineage. CD163 functions as innate immune sensor for gram-positive and gram-negative bacteria. The receptor was discovered in 1987.
Gene data
CD163- Name
- CD163 molecule
- Type
- protein-coding
- Aliases
- M130, MM130, SCARI1
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
via MyGene.info
Gene · Ensembl
CD163 molecule
- Symbol
- CD163
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:7,469,417-7,503,911
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
7,338 papers- Role of CD163 in PRRSV infection.Virology · 2024
- The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology.Cells · 2024
- Soluble CD163.Scandinavian journal of clinical and laboratory investigation · 2012
- CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque.JCI insight · 2023
- Alterations of CD163 expression in the complications of diabetes: A systematic review.Journal of diabetes and its complications · 2022
via PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 128811
- exact match
- identifiers.org/ncbigene/9332
- genomic end
- 7656489
- genomic start
- 7470811
- cytogenetic location
- 12p13.31
via Wikidata · CC0
~3 min read
Article
9 sectionsContents
- Structure
- Clinical significance
- Differences between mouse and human
- Animal studies
- Interactions
- See also
- References
- Further reading
- External links
CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. It also is a marker of cells from the monocyte/macrophage lineage. CD163 functions as innate immune sensor for gram-positive and gram-negative bacteria. The receptor was discovered in 1987.
== Structure ==