DCK

Name

deoxycytidine kinase

Type

protein-coding

Position

70,992,538–71,030,914 (+)

Ensembl

ENSG00000156136

RefSeq RNA

NM_000788.3, XM_047449689.1, XM_054349068.1

RefSeq protein

NP_000779.1, XP_047305645.1, XP_054205043.1

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008].