IFI16

Also known as IFNGIP1, PYHIN2, interferon gamma inducible protein 16

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

In the Vinony graph

Within Vinony's link graph, IFI16 is referenced by 818 other articles, and connects out to Q180686, human chromosome 1 and homeobox.

It is catalogued under topics including Genes on human chromosome 1, Long stubs with short prose and Transcription factors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

IFI16

Name: interferon gamma inducible protein 16
Type: protein-coding
Position: 158,999,938–159,055,156 (+)
Aliases: IFNGIP1, PYHIN2
Ensembl: ENSG00000163565
RefSeq RNA: NM_001206567.2, NM_001364867.2, NM_001376587.1, NM_001376588.1, NM_001376589.1
RefSeq protein: NP_001193496.1, NP_001351796.1, NP_001363516.1, NP_001363517.1, NP_001363518.1

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].

Pathways

NOD-like receptor signaling pathway - Homo sapiens (human)Innate Immune System Immune System STING mediated induction of host immune responses Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Senescence and Autophagy in Cancer

via MyGene.info

Gene · Ensembl

interferon gamma inducible protein 16

Symbol: IFI16
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:158,999,938-159,055,156
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IFI16 PDB 2oq0.png

Show 5 more facts

HomoloGene ID: 115929
genomic start: 158969758
exact match: identifiers.org/ncbigene/3428
genomic end: 159024945
cytogenetic location: 1q23.1

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

== Function ==

Excerpted from Wikipedia’s “IFI16” article, available under the CC BY-SA 4.0 licence.