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GeneQ18031958· pop 5· linked from 820 articles

NR2F1

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Also known as BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

In the Vinony graph

Within Vinony's link graph, NR2F1 is referenced by 820 other articles, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 5, Intracellular receptors and Transcription factors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

NR2F1

Name: nuclear receptor subfamily 2 group F member 1
Type: protein-coding
Position: 93,583,222–93,594,611 (+)
Aliases: BBOAS, BBSOAS, COUP-TFI, COUPTF1, EAR-3, EAR3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1
Ensembl: ENSG00000175745
RefSeq RNA: NM_001410754.1, NM_005654.6
RefSeq protein: NP_001397683.1, NP_005645.1

The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription signal transduction nervous system development nervous system development negative regulation of neuron projection development cell differentiation

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity nuclear receptor activity

Cellular component

nucleus nucleus nucleus nucleoplasm

Pathways

Generic Transcription Pathway Nuclear Receptor transcription pathway RNA Polymerase II Transcription Gene expression (Transcription)Nuclear receptors Adipogenesis

via MyGene.info

Gene · Ensembl

nuclear receptor subfamily 2 group F member 1

Symbol: NR2F1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:93,583,222-93,594,611
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 21158
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7025
chromosome: human chromosome 5
genomic start: 93583222
genomic end: 93594611
cytogenetic location: 5q15

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

6 sections

Contents

Function
Interactions
Clinical
References
External links
Further reading

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

== Function ==

Excerpted from Wikipedia’s “NR2F1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 5 Intracellular receptors Transcription factors