REST

Also known as 2610008J04Rik, AA407358, NRSF, XBR, REST4, WT6, RE1 silencing transcription factor

protein-coding gene in the species Homo sapiens

Gene data

REST

Name: RE1 silencing transcription factor
Type: protein-coding
Aliases: DFNA27, GINGF5, HGF5, NRSF, WT6, XBR

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018].

via MyGene.info