GPR151

Also known as GALR4, GALRL, GPCR, PGR7, G protein-coupled receptor 151, GPCR-2037

G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene. It is weakly activated by galanin, but its endogenous ligand remains unknown. Studies have suggested GPR151 may play a role in several clinically significant processes such as inflammation, pain perception and reward-seeking behavior as well as hepatic glucose production, but further research into its function has been limited so far by a lack of selective agonists and antagonists for this receptor, with most research to date using knockout mice.

Gene data

GPR151

Name: G protein-coupled receptor 151
Type: protein-coding
Aliases: GALR4, GALRL, GPCR, GPCR-2037, PGR7

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017].

via MyGene.info