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GeneQ18026892· pop 5· linked from 813 articles

HIC1

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Also known as ZBTB29, ZNF901, hic-1, hypermethylated in cancer 1, HIC ZBTB transcriptional repressor 1

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.

In the Vinony graph

Vinony's link graph records 813 inbound references to HIC1, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 17 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

HIC1

Name: HIC ZBTB transcriptional repressor 1
Type: protein-coding
Position: 2,054,154–2,063,241 (+)
Aliases: ZBTB29, ZNF901, hic-1
Ensembl: ENSG00000177374
RefSeq RNA: NM_001098202.1, NM_006497.4
RefSeq protein: NP_001091672.1, NP_006488.2

This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage regulation of signal transduction

Molecular function

DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding histone deacetylase binding sequence-specific DNA binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm

Pathways

SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors Metabolism of proteins Post-translational protein modification

via MyGene.info

Gene · Ensembl

HIC ZBTB transcriptional repressor 1

Symbol: HIC1
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:2,054,154-2,063,241
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 4740
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3090
genomic end: 1962981
genomic start: 1957448
chromosome: human chromosome 17
cytogenetic location: 17p13.3
expressed in: pericardium

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.

==References==

Excerpted from Wikipedia’s “HIC1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 17 Transcription factors