ETV1

Name

ETS variant transcription factor 1

Type

protein-coding

Position

13,891,229–13,991,425 (−)

Aliases

ER81

Ensembl

ENSG00000006468

RefSeq RNA

NM_001163147.2, NM_001163148.2, NM_001163149.2, NM_001163150.2, NM_001163151.2

RefSeq protein

NP_001156619.1, NP_001156620.1, NP_001156621.1, NP_001156622.1, NP_001156623.1

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016].

via MyGene.info

Gene · Ensembl

ETS variant transcription factor 1

Symbol

ETV1

Biotype

Protein coding

Organism

Homo sapiens

Location

7:13,891,229-13,991,425

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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