TCF7

Also known as TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

Gene data

TCF7

Name: transcription factor 7
Type: protein-coding
Aliases: TCF-1

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016].

via MyGene.info