BCL11A
Sign in to saveAlso known as BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, EVI9, HBFQTL5, ZNF856
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.
Gene data
BCL11A- Name
- BCL11 transcription factor A
- Type
- protein-coding
- Aliases
- CTIP1, DILOS, EVI9, HBFQTL5, SMARCM1, ZNF856
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
BCL11 transcription factor A
- Symbol
- BCL11A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:60,450,520-60,554,467
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11284
- exact match
- identifiers.org/ncbigene/53335
- genomic end
- 60554467
- genomic start
- 60450520
- cytogenetic location
- 2p16.1
Sources (6)
via Wikidata · CC0
~3 min read
Article
6 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.
== Function ==
Available in 6 languages
via Wikidata sitelinks · CC0