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GeneQ18040602· pop 6· linked from 819 articles

BCL11A

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Also known as BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, EVI9, HBFQTL5, ZNF856

B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.

In the Vinony graph

Vinony's link graph records 819 inbound references to BCL11A, and connects out to PubMed, homeobox and Ensembl genome database project.

Vinony files it under Genes on human chromosome 2 and Transcription factors.

Vinony links it to 6 Wikipedia language editions.

Gene data

BCL11A

Name: BCL11 transcription factor A
Type: protein-coding
Position: 60,450,520–60,554,467 (−)
Aliases: CTIP1, DILOS, EVI9, HBFQTL5, SMARCM1, ZNF856
Ensembl: ENSG00000119866
RefSeq RNA: NM_001363864.1, NM_001365609.1, NM_001405708.1, NM_001405709.1, NM_001405710.1
RefSeq protein: NP_001350793.1, NP_001352538.1, NP_001392637.1, NP_001392638.1, NP_001392639.1

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of gene expression positive regulation of neuron projection development negative regulation of neuron projection development protein sumoylation negative regulation of protein homooligomerization

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription coregulator activity protein binding protein kinase binding

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm nucleoplasm chromosome chromosome

Pathways

Disease Chromatin organization Chromatin organization Diseases of signal transduction by growth factor receptors and second messengers Signaling by ALK in cancer ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants ATP-dependent chromatin remodelers ATP-dependent chromatin remodelers SWI/SNF chromatin remodelers

via MyGene.info

Gene · Ensembl

BCL11 transcription factor A

Symbol: BCL11A
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:60,450,520-60,554,467
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 11284
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/53335
genomic end: 60554467
genomic start: 60450520
chromosome: human chromosome 2
cytogenetic location: 2p16.1
expressed in: superior frontal gyrus

Sources (6)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections

Contents

Function
Clinical significance
Interactions
References
Further reading
External links

B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.

== Function ==

Excerpted from Wikipedia’s “BCL11A” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 2 Transcription factors