CTSF

Also known as CATSF, CLN13, cathepsin F

protein-coding gene in the species Homo sapiens (Humans)

Gene data

CTSF

Name: cathepsin F
Type: protein-coding
Position: 66,563,463–66,568,879 (−)
Aliases: CATSF, CLN13
Ensembl: ENSG00000174080
RefSeq RNA: NM_003793.4, XM_011545328.3, XM_054370356.1
RefSeq protein: NP_003784.2, XP_011543630.1, XP_054226331.1

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008].